A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats

We compared the effects of a nitric oxide (NO)-releasing sildenafil (NCX-911), NO-independent soluble guanylate cyclase activator (BAY41-2272) and sildenafil on the anococcygeus muscle from streptozotocin-induced 16-weeks diabetic rats. NCX-911, BAY41-2272 and sildenafil reduced the phenylephrine-in...

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Veröffentlicht in:	International journal of impotence research 2004-12, Vol.16 (6), p.479-485
Hauptverfasser:	KALSI, Jasjit S, RALPH, David J, MADGE, David J, KELL, Phil D, CELLEK, Selim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Anal Canal Animals Biological and medical sciences Diabetes Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Electric Stimulation Endocrine pancreas. Apud cells (diseases) Endocrinopathies Erectile dysfunction Etiopathogenesis. Screening. Investigations. Target tissue resistance Gynecology. Andrology. Obstetrics Male Male genital diseases Medical sciences Muscle Relaxation - drug effects Muscles - drug effects Muscles - innervation Nitrergic Neurons - drug effects Nitrergic Neurons - physiology Nitric oxide Non tumoral diseases Phenylephrine - pharmacology Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Pyrazoles - pharmacology Pyridines - pharmacology Rats Rats, Wistar Rodents Sacrococcygeal Region Sildenafil Citrate Sulfones
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Zusammenfassung:	We compared the effects of a nitric oxide (NO)-releasing sildenafil (NCX-911), NO-independent soluble guanylate cyclase activator (BAY41-2272) and sildenafil on the anococcygeus muscle from streptozotocin-induced 16-weeks diabetic rats. NCX-911, BAY41-2272 and sildenafil reduced the phenylephrine-induced tone in the control group (EC50=1088.8+/-165.0, 151.6+/-9.3 and 827.1+/-167.3 nM, respectively). The potencies of NCX-911 and BAY41-2272 were not altered, but that of sildenafil was significantly reduced in the diabetic group. EC50 values for NCX-911, BAY41-2272 and sildenafil in the diabetic group were 1765.9+/-303.5, 209.7+/-27.3 and 2842.2+/-640.3 nM, respectively (P
ISSN:	0955-9930 1476-5489
DOI:	10.1038/sj.ijir.3901224