The death of a dogma?

The one lymphocyte–one receptor idea is challenged by the recent finding of B cells capable of producing two functional immunoglobulin molecules. Such cells that survive selection might potentially contribute to autoimmunity.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2004-12, Vol.5 (12), p.1199-1201
1. Verfasser:	Melchers, Fritz
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antibody Diversity - immunology Antibody Specificity Autoimmunity - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Cell Differentiation Cell Survival Gene Rearrangement, B-Lymphocyte - genetics Humans Immunoglobulins - biosynthesis Immunoglobulins - genetics Immunoglobulins - immunology Immunology Infectious Diseases Models, Immunological news-and-views
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Beschreibung
Zusammenfassung:	The one lymphocyte–one receptor idea is challenged by the recent finding of B cells capable of producing two functional immunoglobulin molecules. Such cells that survive selection might potentially contribute to autoimmunity.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni1204-1199