TiO2 Nanotube Surfaces: 15 nm—An Optimal Length Scale of Surface Topography for Cell Adhesion and Differentiation

TiO2 Nanotube Surfaces: 15 nm—An Optimal Length Scale of Surface Topography for Cell Adhesion and Differentiation

Using aligned TiO2 nanotubes with different diameters in the range between 15 and 100 nm synthesized on titanium by an electrochemical approach, it is shown that 15 nm is a universal surface geometric constant that promotes cell adhesion, proliferation, migration, and differentiation of different ce...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2009-03, Vol.5 (6), p.666-671
Hauptverfasser: Park, Jung, Bauer, Sebastian, Schlegel, Karl Andreas, Neukam, Friedrich W., von der Mark, Klaus, Schmuki, Patrik
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatible Materials - chemistry
biomimetics
Cell Adhesion
Cell Culture Techniques - methods
Cell Differentiation
Cells, Cultured
Crystallization - methods
Humans
Macromolecular Substances - chemistry
Materials Testing
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
Molecular Conformation
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
nanotubes
Particle Size
stem cells
Surface Properties
surface topography
Tissue Engineering - methods
Titanium - chemistry
titanium dioxide
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Zusammenfassung:Using aligned TiO2 nanotubes with different diameters in the range between 15 and 100 nm synthesized on titanium by an electrochemical approach, it is shown that 15 nm is a universal surface geometric constant that promotes cell adhesion, proliferation, migration, and differentiation of different cell types (such as mesenchymal stem cells and hematopoietic stem cells; see image).
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200801476