Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion

Abstract The standard mode of administration of piperacillin treatment is by intermittent infusion. However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time-dependent antibacterial activity. In previous studies, we found a higher rate of clinical cure of ventilator-assoc...

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Veröffentlicht in:	International journal of antimicrobial agents 2009-05, Vol.33 (5), p.464-468
Hauptverfasser:	Lorente, Leonardo, Jiménez, Alejandro, Martín, María M, Iribarren, José Luis, Jiménez, Juan José, Mora, María L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Cohort Studies Continuous infusion Female General aspects Gram-negative bacilli Human infectious diseases. Experimental studies and models Humans Infectious Disease Infectious diseases Infusions, Intravenous Intermittent infusion Male Medical sciences Microbial Sensitivity Tests Middle Aged Penicillanic Acid - administration & dosage Penicillanic Acid - analogs & derivatives Penicillanic Acid - pharmacology Penicillanic Acid - therapeutic use Pharmacology. Drug treatments Piperacillin Piperacillin - administration & dosage Piperacillin - pharmacology Piperacillin - therapeutic use Pneumonia, Bacterial - drug therapy Pneumonia, Ventilator-Associated - drug therapy Treatment Outcome Ventilator-associated pneumonia
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