Signaling pathways in Th2 development

In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell‐mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T‐helper (Th) cells orchestrate the immune response and are d...

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Veröffentlicht in:	Immunological reviews 2004-12, Vol.202 (1), p.203-222
Hauptverfasser:	Mowen, Kerri A., Glimcher, Laurie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cytokines - physiology Dendritic Cells - physiology Digestive System - parasitology Humans Mice Signal Transduction - physiology T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - physiology Th2 Cells - cytology Th2 Cells - physiology Transcription Factors - physiology
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Beschreibung
Zusammenfassung:	In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell‐mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T‐helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
ISSN:	0105-2896 1600-065X
DOI:	10.1111/j.0105-2896.2004.00209.x