Numerical characterization of DNA sequences based on digital signal method

Numerical characterization of DNA sequences based on digital signal method

Abstract Based on digital signal method, we propose a new representation of DNA primary sequence. The representation can completely avoid loss of information in the transfer of data from a DNA sequence to its mathematical representation. Afterwards, we suggest one such approach to reach quantificati...

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Veröffentlicht in:Computers in biology and medicine 2009-04, Vol.39 (4), p.388-391
Hauptverfasser: Qi, Zhao-Hui, Qi, Xiao-Qin
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Animals
Base Sequence
Beta-globin gene
beta-Globins - chemistry
beta-Globins - genetics
Computational Biology - methods
Computer Simulation
Deoxyribonucleic acid
Digital broadcasting
DNA
DNA - genetics
DNA sequence
Exons
Genetics
Humans
Internal Medicine
Models, Theoretical
Nucleic Acid Conformation
Other
Reproducibility of Results
Sequence analysis
Sequence Analysis, DNA - methods
Sequence representation
Signal processing
Signal similarity
Species Specificity
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Zusammenfassung:Abstract Based on digital signal method, we propose a new representation of DNA primary sequence. The representation can completely avoid loss of information in the transfer of data from a DNA sequence to its mathematical representation. Afterwards, we suggest one such approach to reach quantification of similarities based on digital signal similarity theory. The examination of similarities/dissimilarities among the coding sequences of the first exon of β-globin gene of 11 species shows the utility of the scheme.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2009.01.009