Synthesis of Enantiopure Imidazolines through a Ritter Reaction of 2-(1-Aminoalkyl)aziridines with Nitriles
The Ritter reaction of enantiopure 2-(1-aminoalkyl)aziridines 1 with different nitriles afford enantiopure tetrasubstituted imidazolines 2. The opening of the aziridine ring takes place with total regio- and stereoselectivity. A mechanism to explain the described addition reaction is proposed.
Gespeichert in:
Veröffentlicht in: | Organic letters 2004-11, Vol.6 (24), p.4499-4501 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The Ritter reaction of enantiopure 2-(1-aminoalkyl)aziridines 1 with different nitriles afford enantiopure tetrasubstituted imidazolines 2. The opening of the aziridine ring takes place with total regio- and stereoselectivity. A mechanism to explain the described addition reaction is proposed. |
---|---|
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol048176j |