Interleukin-10 in viral diseases and cancer: exiting the labyrinth?

Interleukin‐10 (IL‐10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL‐10 in chronic viral diseases and cancer. In the present...

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Veröffentlicht in:	Immunological reviews 2004-12, Vol.202 (1), p.223-236
Hauptverfasser:	Vicari, Alain P., Trinchieri, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Cells - drug effects Humans Interleukin-10 - metabolism Interleukin-10 - therapeutic use Neoplasms - metabolism Tumor Cells, Cultured Virus Diseases - drug therapy Virus Diseases - metabolism
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Zusammenfassung:	Interleukin‐10 (IL‐10) is unique among cytokines, as it is considered both as a potent immunostimulatory and immunosuppressive factor. This complex biology has been particularly challenging when trying to define the useful or harmful role of IL‐10 in chronic viral diseases and cancer. In the present review, we emphasize how these multiple roles define IL‐10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens.
ISSN:	0105-2896 1600-065X
DOI:	10.1111/j.0105-2896.2004.00216.x