Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7

5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally...

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Veröffentlicht in:	Archives of pharmacal research 2004-10, Vol.27 (10), p.990-996
Hauptverfasser:	Ryu, Chung-Kyu, Shim, Ju-Yeon, Yi, You-Jin, Choi, Ik Hwa, Chae, Mi Jin, Han, Ja-Young, Jung, Ok-Jai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Aspergillus niger - drug effects Candida - drug effects Chromatography, Thin Layer Fungi - drug effects Indicators and Reagents Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Quinazolines - chemical synthesis Quinazolines - pharmacology Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02975419