Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2009-05, Vol.44 (5), p.2202-2210
Hauptverfasser:	Zhang, Datong, Wang, Zongheng, Xu, Weiren, Sun, Fanggang, Tang, Lida, Wang, Jianwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinonin derivatives Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Benzimidazole Benzimidazoles - chemistry Biological and medical sciences Drug Design Hydroxamic Acids - chemical synthesis Hydroxamic Acids - pharmacology Klebsiella pneumoniae - drug effects Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Sarcina - drug effects Staphylococcus aureus - drug effects Structure-Activity Relationship Synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound 1a with unsubstituted benzimidazole ring exhibited potent antibacterial activities. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2008.05.009