A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels-Alder and oxidative dearomatization-cyclization reactions

A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels-Alder and oxidative dearomatization-cyclization reactions

A unified strategy towards the facile construction of the [6.7.6.5] oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA) and oxidative dearomatization-cyclization reactions as key steps.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (6), p.662-664
Hauptverfasser: Liu, Lianzhu, Gao, Yingxiang, Che, Chao, Wu, Na, Wang, David Zhigang, Li, Chuang-Chuang, Yang, Zhen
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cyclization
Humans
Models, Chemical
Neuropeptides - chemical synthesis
Neuropeptides - chemistry
Oxidation-Reduction
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Zusammenfassung:A unified strategy towards the facile construction of the [6.7.6.5] oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA) and oxidative dearomatization-cyclization reactions as key steps.
ISSN:1359-7345
1364-548X
DOI:10.1039/b817376a