ALTERNATIVE, AGE- AND VIRAL LOAD-RELATED ROUTES OF NELFINAVIR RESISTANCE IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1-INFECTED CHILDREN RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY

To assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant...

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Veröffentlicht in:The Pediatric infectious disease journal 2004-11, Vol.23 (11), p.1057-1059
Hauptverfasser: Machado, Elizabeth S, Lambert, John S, Afonso, Adriana O, Cunha, Silvia M, Oliveira, Ricardo H, Tanuri, Amilcar, Sill, Anne M, Costa, Antonio J. L, Soares, Marcelo A
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Sprache:eng
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Zusammenfassung:To assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant correlation with a higher viral load and lower age and the occurrence of L90M. These findings suggest differential molecular age- and viral load-related routes for nelfinavir resistance.
ISSN:0891-3668
1532-0987
DOI:10.1097/01.inf.0000145874.88351.0f