Hyperalgesia in the setting of anxiety: Sex differences and effects of the oestrous cycle in Wistar rats

Summary Sex differences to noxious thermal cutaneous stimulation were compared in Wistar rats. Male and female rats showed similar baseline tail flick latencies. However, sex differences emerged when nociceptive testing was carried out in the setting of mild non-noxious anxiogenic stress (4 Hz vibra...

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Veröffentlicht in:	Psychoneuroendocrinology 2009-05, Vol.34 (4), p.587-596
Hauptverfasser:	Devall, Adam J, Liu, Zhao-Wei, Lovick, Thelma A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Anxiety - complications Anxiety - psychology Behavioral psychophysiology Biological and medical sciences Endocrinology & Metabolism Estrous Cycle - physiology Exploratory Behavior - physiology Female Fundamental and applied biological sciences. Psychology Hormones and behavior Hyperalgesia - complications Hyperalgesia - psychology Male Oestrous cycle Pain Threshold - physiology Pain Threshold - psychology Progesterone - physiology Progesterone withdrawal Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Wistar Reaction Time - physiology Stress, Physiological - physiology Stress-induced hyperalgesia Tail flick reflex Vibration
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Zusammenfassung:	Summary Sex differences to noxious thermal cutaneous stimulation were compared in Wistar rats. Male and female rats showed similar baseline tail flick latencies. However, sex differences emerged when nociceptive testing was carried out in the setting of mild non-noxious anxiogenic stress (4 Hz vibration for 5 min). On cessation of vibration stress 16/35 (46%) of male rats showed hyperalgesia (decrease in tail flick latency lasting >20 min) whist the reminder showed a brief (
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2008.10.021