Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception
This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-vi...
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| Veröffentlicht in: | Brain research 2004-12, Vol.1029 (1), p.124-130 |
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| creator | Göktalay, Gökhan Levendusky, Mark C. Millington, William R. |
| description | This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals. |
| doi_str_mv | 10.1016/j.brainres.2004.09.029 |
| format | Article |
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Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2004.09.029</identifier><identifier>PMID: 15533324</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Bradycardia - etiology ; Bradycardia - physiopathology ; Cardiovascular Physiological Phenomena ; Cardiovascular regulation ; Fundamental and applied biological sciences. 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Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - etiology</subject><subject>Bradycardia - physiopathology</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cardiovascular regulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA Agonists - administration & dosage</subject><subject>GABA receptor</subject><subject>Homocysteine - administration & dosage</subject><subject>Homocysteine - analogs & derivatives</subject><subject>Hypotension - etiology</subject><subject>Hypotension - physiopathology</subject><subject>Hypothalamic Area, Lateral - drug effects</subject><subject>Lateral hypothalamus</subject><subject>Male</subject><subject>Microinjections</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Muscimol</subject><subject>Muscimol - administration & dosage</subject><subject>Pain</subject><subject>Pain - complications</subject><subject>Pain - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visceral nociception</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS1ERaeFv1BlA7sEvxPvQFVbkIq6gbV1YzsajxJ7sJNKs-pfx5kZ1GU3ft3v3Hvkg9ANwQ3BRH7dNX0CH5LLDcWYN1g1mKp3aEO6ltaScvwebTDGsu6UYpfoKudduTKm8Ad0SYRgjFG-QS-_lmz8FMfKh50zs4-hnOZYzVtXjTC7BGO1PezjvIURpiWX6tb3fs5H4lhxIa8yCLYqpuzBQLIeKgNLduXpUOU4wRzrZ5_NsV-Ixhu3X4d9RBcDjNl9Ou_X6M_93e_bH_Xj08PP2--PteFUzHUHvB_KwoF3DBsl2x46TkhPGXdCgRR0UML1vcVMtaCEFS211IDtrByIYtfoy6nvPsW_i8uznlY34wjBxSVr2WKhqMJvgqTlikssCyhPoEkx5-QGvU9-gnTQBOs1I73T_zPSa0YaK10yKsKb84Sln5x9lZ1DKcDnMwDZwDgkCMbnV07STki1Ovh24lz5uGfvki5RumCc9alEqW30b3n5B8_wtoI</recordid><startdate>20041210</startdate><enddate>20041210</enddate><creator>Göktalay, Gökhan</creator><creator>Levendusky, Mark C.</creator><creator>Millington, William R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20041210</creationdate><title>Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception</title><author>Göktalay, Gökhan ; Levendusky, Mark C. ; Millington, William R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-8a4bf8a44a4830c967ba8411b234e59a652f95ebbd0397a95d572d2cad8d6f193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bradycardia - etiology</topic><topic>Bradycardia - physiopathology</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Cardiovascular regulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA Agonists - administration & dosage</topic><topic>GABA receptor</topic><topic>Homocysteine - administration & dosage</topic><topic>Homocysteine - analogs & derivatives</topic><topic>Hypotension - etiology</topic><topic>Hypotension - physiopathology</topic><topic>Hypothalamic Area, Lateral - drug effects</topic><topic>Lateral hypothalamus</topic><topic>Male</topic><topic>Microinjections</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Muscimol</topic><topic>Muscimol - administration & dosage</topic><topic>Pain</topic><topic>Pain - complications</topic><topic>Pain - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visceral nociception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Göktalay, Gökhan</creatorcontrib><creatorcontrib>Levendusky, Mark C.</creatorcontrib><creatorcontrib>Millington, William R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Göktalay, Gökhan</au><au>Levendusky, Mark C.</au><au>Millington, William R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2004-12-10</date><risdate>2004</risdate><volume>1029</volume><issue>1</issue><spage>124</spage><epage>130</epage><pages>124-130</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>15533324</pmid><doi>10.1016/j.brainres.2004.09.029</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Bradycardia - etiology Bradycardia - physiopathology Cardiovascular Physiological Phenomena Cardiovascular regulation Fundamental and applied biological sciences. Psychology GABA Agonists - administration & dosage GABA receptor Homocysteine - administration & dosage Homocysteine - analogs & derivatives Hypotension - etiology Hypotension - physiopathology Hypothalamic Area, Lateral - drug effects Lateral hypothalamus Male Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Muscimol Muscimol - administration & dosage Pain Pain - complications Pain - physiopathology Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs Visceral nociception |
| title | Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception |
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