Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception

This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-vi...

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Veröffentlicht in:Brain research 2004-12, Vol.1029 (1), p.124-130
Hauptverfasser: Göktalay, Gökhan, Levendusky, Mark C., Millington, William R.
Format: Artikel
Sprache:eng
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Zusammenfassung:This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocaine (2%; 0.1, 0.3 or 1.0 μl) or muscimol (0.34 nmol; 0.5 μl) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2004.09.029