Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer

Abstract HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in thi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2009-05, Vol.30 (15), p.2912-2918
Hauptverfasser:	Chen, Chuang, Peng, Jun, Xia, He-Shun, Yang, Gui-Fang, Wu, Qiong-Shui, Chen, Liang-Dong, Zeng, Li-Bo, Zhang, Zhi-Ling, Pang, Dai-Wen, Li, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Breast cancer Breast Neoplasms - genetics Dentistry Feasibility Studies Fluorescence in situ hybridization Fluorescent Antibody Technique Genes, erbB-2 HER2 Humans Immunohistochemistry Quantum Dots Sensitivity and Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in this paper. A QDs HER2 probe kit and QDs image acquisition and analysis software were developed and applied to 94 clinical samples of BC. Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis.
ISSN:	0142-9612 1878-5905
DOI:	10.1016/j.biomaterials.2009.02.010