Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function

The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activit...

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Veröffentlicht in:	Endocrine 2009-04, Vol.35 (2), p.189-197
Hauptverfasser:	Jorge, Angélica Gobbi, Módulo, Carolina Maria, Dias, Ana Carolina, Braz, Alexandre Martins, Filho, Rubens Bertazolli, Jordão, Alceu A., de Paula, Jayter Silva, Rocha, Eduardo Melani
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - therapeutic use Cell Nucleus - pathology Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Endocrinology Humanities and Social Sciences Internal Medicine Ion Channels - analysis Lacrimal Apparatus - pathology Lacrimal Apparatus - physiopathology Male Medicine Medicine & Public Health Mitochondrial Proteins - analysis multidisciplinary Original Paper Oxidative Stress - drug effects Peroxidase - analysis Peroxidase - metabolism Rats Rats, Wistar Science Tears - secretion Uncoupling Protein 1 Uncoupling Protein 2 Uncoupling Protein 3
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Zusammenfassung:	The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activity, and expression of uncoupling proteins (UCPs). DM reduction of tear secretion was prevented by aspirin ( P
ISSN:	1355-008X 1559-0100
DOI:	10.1007/s12020-009-9151-9