Synthesis of fused pyran-carbahexopyranoses as glycosidase inhibitors

Synthesis of fused pyran-carbahexopyranoses as glycosidase inhibitors

Synthesis of polyhydroxylated oxabicyclo[4,4,0]decanes, which constitute a new family of annulated carbasugars, has been accomplished in a stereoselective manner by employing readily available 1,2-anhydro-3,4,6-tri- O-benzyl-α- d-glycopyranoses.

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Veröffentlicht in:Carbohydrate research 2009-03, Vol.344 (5), p.606-612
Hauptverfasser: Doddi, Venkata Ramana, Kancharla, Pavan K., Reddy, Y. Suman, Kumar, Amit, Vankar, Yashwant D.
Format: Artikel
Sprache:eng
Schlagworte:
Carbasugars
Carbasugars - chemical synthesis
Carbasugars - chemistry
Carbasugars - pharmacology
Glycosidase inhibitors
Glycoside Hydrolases - antagonists & inhibitors
Hybrid sugars
Magnetic Resonance Spectroscopy
Molecular Structure
Pyrans - chemistry
Stereoisomerism
Structure-Activity Relationship
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Beschreibung
Zusammenfassung:Synthesis of polyhydroxylated oxabicyclo[4,4,0]decanes, which constitute a new family of annulated carbasugars, has been accomplished in a stereoselective manner by employing readily available 1,2-anhydro-3,4,6-tri- O-benzyl-α- d-glycopyranoses.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2009.01.017