Early-Life Sodium Exposure Unmasks Susceptibility to Stroke in Hyperlipidemic, Hypertensive Heterozygous Tg25 Rats Transgenic for Human Cholesteryl Ester Transfer Protein

Early-Life Sodium Exposure Unmasks Susceptibility to Stroke in Hyperlipidemic, Hypertensive Heterozygous Tg25 Rats Transgenic for Human Cholesteryl Ester Transfer Protein

Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications. We investigated the effects of early-life Na exposure (0.23% versus 0.4% NaCl regular rat chow) on vascular disease...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2009-03, Vol.119 (11), p.1501-1509
Hauptverfasser: DECANO, Julius L, VIERECK, Jason C, MCKEE, Ann C, HAMILTON, James A, RUIZ-OPAZO, Nelson, HERRERA, Victoria L. M
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Biological and medical sciences
Blood and lymphatic vessels
Brain - blood supply
Brain - pathology
Cardiology. Vascular system
Carotid Artery Diseases - diagnostic imaging
Cholesterol Ester Transfer Proteins - genetics
Disease Models, Animal
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Hyperlipidemias - complications
Hyperlipidemias - genetics
Hypertension - complications
Hypertension - genetics
Magnetic Resonance Imaging
Male
Medical sciences
Microcirculation
Neurology
Phenotype
Rats
Rats, Inbred Dahl
Rats, Transgenic
Sex Factors
Sodium Chloride, Dietary - pharmacology
Stroke - complications
Stroke - genetics
Stroke - pathology
Ultrasonography
Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:Early-life risk factor exposure increases aortic atherosclerosis and blood pressure in humans and animal models; however, limited insight has been gained as to end-organ complications. We investigated the effects of early-life Na exposure (0.23% versus 0.4% NaCl regular rat chow) on vascular disease outcomes using the inbred, transgenic [hCETP](25) Dahl salt-sensitive hypertensive rat model of male-predominant coronary atherosclerosis, Tg25. Rather than the expected increase in coronary heart disease, fetal 0.4% Na exposure (< or =2 g of Na per 2-kcal/d diet) induced adult-onset stroke in both sexes (ANOVA P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.108.833327