Plasmablastic Lymphoma Affecting the Lung and Bone Marrow With CD10 Expression and t(8;14)(q24;q32) Translocation

Plasmablastic Lymphoma Affecting the Lung and Bone Marrow With CD10 Expression and t(8;14)(q24;q32) Translocation

Plasmablastic lymphoma is a rare variant of a diffuse, large B-cell lymphoma, which typically presents in the oral cavity in immunocompromised patients. In HIV positive patients, this tumor has a tendency to manifest in extramedullary sites. In this report, we document a rare instance in which this...

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Veröffentlicht in:International journal of surgical pathology 2009-04, Vol.17 (2), p.163-166
Hauptverfasser: Khoon Leong Chuah, Siok Bian Ng, Poon, Limei, Wai Ming Yap
Format: Artikel
Sprache:eng
Schlagworte:
Bone Marrow Neoplasms - diagnosis
Bone Marrow Neoplasms - metabolism
Bone Marrow Neoplasms - pathology
Burkitt Lymphoma - diagnosis
Burkitt Lymphoma - metabolism
Burkitt Lymphoma - pathology
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 8
Diagnosis, Differential
Human immunodeficiency virus
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - metabolism
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Middle Aged
Neprilysin - metabolism
Translocation, Genetic - genetics
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Zusammenfassung:Plasmablastic lymphoma is a rare variant of a diffuse, large B-cell lymphoma, which typically presents in the oral cavity in immunocompromised patients. In HIV positive patients, this tumor has a tendency to manifest in extramedullary sites. In this report, we document a rare instance in which this neoplasm besides affecting the bone marrow also involved the lung. In addition, the lymphoma in our case disclosed CD10 positivity on immunohistochemistry and t(8;14)(q24;q34) translocation on cytogenetic analysis, mimicking a Burkitt/atypical Burkitt lymphoma. The problems in diagnosis are discussed.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896908316785