Body mass index, metabolic syndrome and carotid atherosclerosis

OBJECTIVEBody fatness and fat distribution are widely accepted as coronary heart disease risk factors. In this study, we have evaluated the contribution of generalized adiposity, assessed by body mass index (BMI), to carotid atherosclerosis, in participants with or without metabolic syndrome (MetS)....

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Veröffentlicht in:Coronary artery disease 2009-03, Vol.20 (2), p.94-99
Hauptverfasser: Irace, Concetta, Scavelli, Faustina, Carallo, Claudio, Serra, Raffaele, Cortese, Claudio, Gnasso, Agostino
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container_end_page 99
container_issue 2
container_start_page 94
container_title Coronary artery disease
container_volume 20
creator Irace, Concetta
Scavelli, Faustina
Carallo, Claudio
Serra, Raffaele
Cortese, Claudio
Gnasso, Agostino
description OBJECTIVEBody fatness and fat distribution are widely accepted as coronary heart disease risk factors. In this study, we have evaluated the contribution of generalized adiposity, assessed by body mass index (BMI), to carotid atherosclerosis, in participants with or without metabolic syndrome (MetS). METHODSWe have analysed 840 female and 1002 male participants in a regional Cardiovascular Disease Prevention Campaign. Blood glucose and lipids were analysed by standard methods. According to BMI, calculated as weight (in kilograms)/height (in square metres), participants were divided into normal weight (BMI 29.9 kg/m). Carotid atherosclerosis was evaluated by echo Doppler. RESULTSBlood pressure, waist circumference, triglycerides and glucose were significantly higher, and high-density lipoprotein was lower, in overweight and obese participants, compared with normal weight. MetS was more frequent among obese and overweight than normal-weight participants (51.7 vs. 21.5 vs. 9.8%, respectively). The prevalence of carotid atherosclerosis was 45.29% in participants with MetS, significantly higher than in participants without MetS (33.04%, P
doi_str_mv 10.1097/MCA.0b013e3283219e76
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In this study, we have evaluated the contribution of generalized adiposity, assessed by body mass index (BMI), to carotid atherosclerosis, in participants with or without metabolic syndrome (MetS). METHODSWe have analysed 840 female and 1002 male participants in a regional Cardiovascular Disease Prevention Campaign. Blood glucose and lipids were analysed by standard methods. According to BMI, calculated as weight (in kilograms)/height (in square metres), participants were divided into normal weight (BMI &lt;25 kg/m), overweight (BMI between 25 and 29.9 kg/m) and obese (BMI&gt;29.9 kg/m). Carotid atherosclerosis was evaluated by echo Doppler. RESULTSBlood pressure, waist circumference, triglycerides and glucose were significantly higher, and high-density lipoprotein was lower, in overweight and obese participants, compared with normal weight. MetS was more frequent among obese and overweight than normal-weight participants (51.7 vs. 21.5 vs. 9.8%, respectively). The prevalence of carotid atherosclerosis was 45.29% in participants with MetS, significantly higher than in participants without MetS (33.04%, P&lt;0.0001), but it was similar across the three weight categories. Furthermore, in multiple regression analyses BMI was not significantly associated with carotid atherosclerosis. CONCLUSIONThe present findings suggest that increasing body weight favours the clustering of coronary heart disease risk factors. Overweight and obesity, however, do not independently associate with carotid atherosclerosis.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/MCA.0b013e3283219e76</identifier><identifier>PMID: 19293666</identifier><language>eng</language><publisher>England: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Adiposity ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose - analysis ; Blood Pressure ; Body Mass Index ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - etiology ; Female ; Humans ; Italy - epidemiology ; Lipids - blood ; Logistic Models ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Middle Aged ; Obesity - complications ; Obesity - epidemiology ; Obesity - physiopathology ; Odds Ratio ; Overweight - complications ; Overweight - epidemiology ; Overweight - physiopathology ; Prevalence ; Risk Assessment ; Risk Factors ; Smoking - adverse effects ; Ultrasonography, Doppler ; Waist Circumference</subject><ispartof>Coronary artery disease, 2009-03, Vol.20 (2), p.94-99</ispartof><rights>2009 Lippincott Williams &amp; Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4162-d7b50da545ce569b84975bfbe311456fa4f4ff5a3bd02126d48e40fef294c5c13</citedby><cites>FETCH-LOGICAL-c4162-d7b50da545ce569b84975bfbe311456fa4f4ff5a3bd02126d48e40fef294c5c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19293666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irace, Concetta</creatorcontrib><creatorcontrib>Scavelli, Faustina</creatorcontrib><creatorcontrib>Carallo, Claudio</creatorcontrib><creatorcontrib>Serra, Raffaele</creatorcontrib><creatorcontrib>Cortese, Claudio</creatorcontrib><creatorcontrib>Gnasso, Agostino</creatorcontrib><title>Body mass index, metabolic syndrome and carotid atherosclerosis</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>OBJECTIVEBody fatness and fat distribution are widely accepted as coronary heart disease risk factors. In this study, we have evaluated the contribution of generalized adiposity, assessed by body mass index (BMI), to carotid atherosclerosis, in participants with or without metabolic syndrome (MetS). METHODSWe have analysed 840 female and 1002 male participants in a regional Cardiovascular Disease Prevention Campaign. Blood glucose and lipids were analysed by standard methods. According to BMI, calculated as weight (in kilograms)/height (in square metres), participants were divided into normal weight (BMI &lt;25 kg/m), overweight (BMI between 25 and 29.9 kg/m) and obese (BMI&gt;29.9 kg/m). Carotid atherosclerosis was evaluated by echo Doppler. RESULTSBlood pressure, waist circumference, triglycerides and glucose were significantly higher, and high-density lipoprotein was lower, in overweight and obese participants, compared with normal weight. MetS was more frequent among obese and overweight than normal-weight participants (51.7 vs. 21.5 vs. 9.8%, respectively). The prevalence of carotid atherosclerosis was 45.29% in participants with MetS, significantly higher than in participants without MetS (33.04%, P&lt;0.0001), but it was similar across the three weight categories. Furthermore, in multiple regression analyses BMI was not significantly associated with carotid atherosclerosis. CONCLUSIONThe present findings suggest that increasing body weight favours the clustering of coronary heart disease risk factors. Overweight and obesity, however, do not independently associate with carotid atherosclerosis.</description><subject>Adiposity</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Lipids - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity - physiopathology</subject><subject>Odds Ratio</subject><subject>Overweight - complications</subject><subject>Overweight - epidemiology</subject><subject>Overweight - physiopathology</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Ultrasonography, Doppler</subject><subject>Waist Circumference</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLBDEQhIMo7vr4ByJz8uRo5z05iS6-QPGi55BJOuzozI4ms-j-e2dxYcFDd9NQVRQfIScULigYffk8u76AGihHzirOqEGtdsiUCs1LWXHYJVMwUpTKsGpCDnJ-B6BCarlPJtQww5VSU3J104dV0bmci2YR8Oe86HBwdd82vsirRUh9h4VbhMK71A9NKNwwx9Rn3653k4_IXnRtxuPNPSRvd7evs4fy6eX-cXb9VHpBFSuDriUEJ4X0KJWpK2G0rGONnI6dVHQiihil43UARpkKokIBESMzwktP-SE5-8v9TP3XEvNguyZ7bFu3wH6ZrdIgtBZrofgT-rFfThjtZ2o6l1aWgl2DsyM4-x_caDvd5C_rDsPWtCG1zf3u2wFT_miX35jsHF07zC2MbI0EWjIAA3x8y3GA8V8AMHmO</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Irace, Concetta</creator><creator>Scavelli, Faustina</creator><creator>Carallo, Claudio</creator><creator>Serra, Raffaele</creator><creator>Cortese, Claudio</creator><creator>Gnasso, Agostino</creator><general>Lippincott Williams &amp; Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Body mass index, metabolic syndrome and carotid atherosclerosis</title><author>Irace, Concetta ; Scavelli, Faustina ; Carallo, Claudio ; Serra, Raffaele ; Cortese, Claudio ; Gnasso, Agostino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4162-d7b50da545ce569b84975bfbe311456fa4f4ff5a3bd02126d48e40fef294c5c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adiposity</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Lipids - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Obesity - physiopathology</topic><topic>Odds Ratio</topic><topic>Overweight - complications</topic><topic>Overweight - epidemiology</topic><topic>Overweight - physiopathology</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Ultrasonography, Doppler</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irace, Concetta</creatorcontrib><creatorcontrib>Scavelli, Faustina</creatorcontrib><creatorcontrib>Carallo, Claudio</creatorcontrib><creatorcontrib>Serra, Raffaele</creatorcontrib><creatorcontrib>Cortese, Claudio</creatorcontrib><creatorcontrib>Gnasso, Agostino</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irace, Concetta</au><au>Scavelli, Faustina</au><au>Carallo, Claudio</au><au>Serra, Raffaele</au><au>Cortese, Claudio</au><au>Gnasso, Agostino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index, metabolic syndrome and carotid atherosclerosis</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2009-03</date><risdate>2009</risdate><volume>20</volume><issue>2</issue><spage>94</spage><epage>99</epage><pages>94-99</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>OBJECTIVEBody fatness and fat distribution are widely accepted as coronary heart disease risk factors. In this study, we have evaluated the contribution of generalized adiposity, assessed by body mass index (BMI), to carotid atherosclerosis, in participants with or without metabolic syndrome (MetS). METHODSWe have analysed 840 female and 1002 male participants in a regional Cardiovascular Disease Prevention Campaign. Blood glucose and lipids were analysed by standard methods. According to BMI, calculated as weight (in kilograms)/height (in square metres), participants were divided into normal weight (BMI &lt;25 kg/m), overweight (BMI between 25 and 29.9 kg/m) and obese (BMI&gt;29.9 kg/m). Carotid atherosclerosis was evaluated by echo Doppler. RESULTSBlood pressure, waist circumference, triglycerides and glucose were significantly higher, and high-density lipoprotein was lower, in overweight and obese participants, compared with normal weight. MetS was more frequent among obese and overweight than normal-weight participants (51.7 vs. 21.5 vs. 9.8%, respectively). The prevalence of carotid atherosclerosis was 45.29% in participants with MetS, significantly higher than in participants without MetS (33.04%, P&lt;0.0001), but it was similar across the three weight categories. Furthermore, in multiple regression analyses BMI was not significantly associated with carotid atherosclerosis. CONCLUSIONThe present findings suggest that increasing body weight favours the clustering of coronary heart disease risk factors. Overweight and obesity, however, do not independently associate with carotid atherosclerosis.</abstract><cop>England</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>19293666</pmid><doi>10.1097/MCA.0b013e3283219e76</doi><tpages>6</tpages></addata></record>
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source Journals@Ovid Ovid Autoload; MEDLINE
subjects Adiposity
Adult
Aged
Aged, 80 and over
Blood Glucose - analysis
Blood Pressure
Body Mass Index
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - etiology
Female
Humans
Italy - epidemiology
Lipids - blood
Logistic Models
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Middle Aged
Obesity - complications
Obesity - epidemiology
Obesity - physiopathology
Odds Ratio
Overweight - complications
Overweight - epidemiology
Overweight - physiopathology
Prevalence
Risk Assessment
Risk Factors
Smoking - adverse effects
Ultrasonography, Doppler
Waist Circumference
title Body mass index, metabolic syndrome and carotid atherosclerosis
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