Cobalt‐Catalyzed N‐Arylation of Nitrogen Nucleophiles in Water

Cobalt ′n′ cross‐coupling! A facile and practical strategy catalyzed by CoCl2⋅6 H2O has been developed for the N‐arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7‐azaindole, undergo catalysis to afford N‐arylated products in moderate to good yields (up to 86 %; see scheme). Cobalt ′n′ cross‐coupling! A facile and practical strategy catalyzed by CoCl2⋅6 H2O has been developed for the N‐arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7‐azaindole, undergo catalysis to afford N‐arylated products in moderate to good yields (up to 86 %; see scheme).