Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic–ischemic adult rats

The N-terminal tripeptide of insulin-like growth factor-1, GPE is neuroprotective when given intracerebroventricularly 2 h after hypoxic–ischemic (HI) brain injury in rats. We have now examined whether GPE can cross the blood–brain barrier and exert neuroprotective actions following intravenous admi...

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Veröffentlicht in:	Neuropharmacology 2004-11, Vol.47 (6), p.892-903
Hauptverfasser:	Guan, J., Thomas, G.B., Lin, H., Mathai, S., Bachelor, D.C., George, S., Gluckman, P.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult rat Animals Blood–brain barrier Brain Chemistry - drug effects Brain Chemistry - physiology Dose-Response Relationship, Drug Functional Laterality - physiology Glycine-proline-glutamate Half-Life Hippocampus - pathology Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - prevention & control Hypoxia–ischemia Immunohistochemistry In Situ Nick-End Labeling Infusions, Intravenous Insulin-Like Growth Factor I - administration & dosage Insulin-Like Growth Factor I - pharmacokinetics Insulin-Like Growth Factor I - pharmacology Intravenous administration Male Molecular Weight Neurons - pathology Neuroprotection Neuroprotective Agents Oligopeptides - administration & dosage Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Radioimmunoassay Rats Rats, Wistar
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Zusammenfassung:	The N-terminal tripeptide of insulin-like growth factor-1, GPE is neuroprotective when given intracerebroventricularly 2 h after hypoxic–ischemic (HI) brain injury in rats. We have now examined whether GPE can cross the blood–brain barrier and exert neuroprotective actions following intravenous administration. Following a single bolus intravenous injection, GPE was rapidly metabolized and cleared from the circulation. The short half-life (
ISSN:	0028-3908 1873-7064
DOI:	10.1016/j.neuropharm.2004.07.002