Use of monoclonal antibodies for analyses of Coxiella burnetii major antigens

Monoclonal antibodies (MAbs) to major antigens of Coxiella burnetii were produced. Some of the MAbs to a 62-kDa protein antigen, peptidoglycan protein complex and lipopolysaccharide (LPS) O-chains reacted with other bacteria whereas none of the MAbs to outer membrane proteins and LPS outer-core did....

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Veröffentlicht in:	Journal of Veterinary Medical Science 2004, Vol.66(10), pp.1289-1291
Hauptverfasser:	Hotta, A. (National Inst. of Infectious Diseases, Musashimurayama, Tokyo (Japan)), Zhang, G.Q, Andoh, M, Yamaguchi, T, Fukushi, H, Hirai, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology antigenic property ANTIGENS Antigens, Bacterial - immunology Antigens, Bacterial - isolation & purification Blotting, Western COXIELLA BURNETII Coxiella burnetii - immunology DIAGNOSIS Fluorescent Antibody Technique, Indirect Lipopolysaccharides - metabolism MANKIND Membrane Proteins - metabolism MONOCLONAL ANTIBODIES monoclonal antibody Q FEVER
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Zusammenfassung:	Monoclonal antibodies (MAbs) to major antigens of Coxiella burnetii were produced. Some of the MAbs to a 62-kDa protein antigen, peptidoglycan protein complex and lipopolysaccharide (LPS) O-chains reacted with other bacteria whereas none of the MAbs to outer membrane proteins and LPS outer-core did. The LPS outer-core and OMPs may be useful antigens for specifically detecting antibodies to C. burnetii.
ISSN:	0916-7250 1347-7439
DOI:	10.1292/jvms.66.1289