The new DR‐70 immunoassay detects cancer of the gastrointestinal tract: a validation study

Summary Background : Malignant cells characteristically possess high levels of plasminogen activator, which induce local fibrinolysis. The DR‐70 immunoassay is a newly developed test, which quantifies fibrin degradation products in serum by a proprietary antibody. Aim : To evaluate the DR‐70 immunoassay as a detection assay for the presence of gastrointestinal cancers. Methods : We prospectively collected blood sera of 85 patients with histologically proven tumour and 100 healthy blood donors. Ten microlitres of the sera was used for the DR‐70 immunoassay. Nineteen patients had a hepatocellular and 10 cholangiocellular carcinoma, 13 cancer of the pancreas, 30 colorectal cancer, 10 stomach cancer and three cancer of the oesophagus. Results : Receiver–operator curve analysis revealed