Kinetic Control in Noncovalent Synthesis:  Regioselective Ligand Exchange into a Hydrogen Bonded Assembly

Kinetic Control in Noncovalent Synthesis:  Regioselective Ligand Exchange into a Hydrogen Bonded Assembly

This paper illustrates the use of a kinetically controlled exchange reaction to effect regioselective modification of a hydrogen-bonded assembly. Both the bound anion and cation can control the exchange of ligand into the different layers of a synthetic G-quadruplex.

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Veröffentlicht in:Organic letters 2004-11, Vol.6 (23), p.4265-4268
Hauptverfasser: Davis, Jeffery T, Kaucher, Mark S, Kotch, Frank W, Iezzi, Maura A, Clover, Bryna C, Mullaugh, Katherine M
Format: Artikel
Sprache:eng
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Zusammenfassung:This paper illustrates the use of a kinetically controlled exchange reaction to effect regioselective modification of a hydrogen-bonded assembly. Both the bound anion and cation can control the exchange of ligand into the different layers of a synthetic G-quadruplex.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0483089