Matrix metalloproteinases and the gut — new roles for old enzymes

Matrix metalloproteinases and the gut — new roles for old enzymes

Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified. MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and c...

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Veröffentlicht in:Current opinion in pharmacology 2004-12, Vol.4 (6), p.546-550
Hauptverfasser: Pender, Sylvia LF, MacDonald, Thomas T
Format: Artikel
Sprache:eng
Schlagworte:
Extracellular Matrix - drug effects
Extracellular Matrix - metabolism
Gastrointestinal Diseases - enzymology
Gastrointestinal Tract - enzymology
Humans
Matrix Metalloproteinases - metabolism
Matrix Metalloproteinases - pharmacology
United Kingdom
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Zusammenfassung:Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified. MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and cancer. Recent data suggest that MMPs are involved in tissue injury and healing in the human gut.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2004.06.005