Urinary levels of interleukin-6 and interleukin-8 in children with urinary tract infections to age 2

The aim of this study was to assess relations between the clinical course of UTI, IL-6 and IL-8 levels, and the presence of inflammatory changes detected by renal scintigraphy using 99mTc-DMSA (DMSA). We studied 33 children aged 1-24 months (mean 7.1+/-5.8 months) with first-time UTI. The subjects w...

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Veröffentlicht in:	Medical science monitor 2004-11, Vol.10 (11), p.CR593-CR597
Hauptverfasser:	Krzemień, Grazyna, Roszkowska-Blaim, Maria, Kostro, Izabella, Szmigielska, Agnieszka, Karpińska, Monika, Sieniawska, Maria, Bartłomiejczyk, Irena, Paczek, Leszek, Toth, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Child, Preschool Creatinine - urine Female Humans Infant Interleukin-6 - urine Interleukin-8 - urine Kidney - diagnostic imaging Male Radionuclide Imaging Technetium Tc 99m Dimercaptosuccinic Acid Urinary Tract Infections - diagnosis Urinary Tract Infections - diagnostic imaging
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Zusammenfassung:	The aim of this study was to assess relations between the clinical course of UTI, IL-6 and IL-8 levels, and the presence of inflammatory changes detected by renal scintigraphy using 99mTc-DMSA (DMSA). We studied 33 children aged 1-24 months (mean 7.1+/-5.8 months) with first-time UTI. The subjects were divided in two groups: with fever (group I, n=10) and without fever (group II, n=23). Inflammatory markers (ESR, CRP, leukocyte count), urinary IL-6 and IL-8 level, and DMSA scan were evaluated in all children. Urinary IL-6 and IL-8 levels [IL-6, IL-8/creatinine (pg/mg)] were significantly higher in group I than in group II (Il-6 level: 39.4+/-41.1 vs. 6.3+/-13.7, p
ISSN:	1234-1010