Total Synthesis of (-)-Amphidinolide K

Total Synthesis of (-)-Amphidinolide K

Macrolide magic: An enyne cross-metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic β-alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (-)-amphidinolide K.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (13), p.2364-2366
Hauptverfasser: Ko, Haye Min, Lee, Chung Whan, Kwon, Hyung Kyoo, Chung, Hea Seung, Choi, Soo Young, Chung, Young Keun, Lee, Eun
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
anticancer agents
Cyclization
macrolides
Macrolides - chemical synthesis
Macrolides - chemistry
natural products
radical cyclization
Stereoisomerism
total synthesis
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Zusammenfassung:Macrolide magic: An enyne cross-metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic β-alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (-)-amphidinolide K.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200805266