Clinical results of proton beam therapy for skull base chordoma
To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2004-11, Vol.60 (4), p.1120-1126 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Igaki, Hiroshi Tokuuye, Koichi Okumura, Toshiyuki Sugahara, Shinji Kagei, Kenji Hata, Masaharu Ohara, Kiyoshi Hashimoto, Takayuki Tsuboi, Koji Takano, Shingo Matsumura, Akira Akine, Yasuyuki |
| description | To evaluate clinical results of proton beam therapy for patients with skull base chordoma.
Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0–95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6–123.4 months).
The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors |
| doi_str_mv | 10.1016/j.ijrobp.2004.05.064 |
| format | Article |
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Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0–95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6–123.4 months).
The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery.
Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2004.05.064</identifier><identifier>PMID: 15519783</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chordoma - radiotherapy ; Chordoma, Skull base ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Proton beams ; Protons - therapeutic use ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Skull Base Neoplasms - radiotherapy ; Technology. Biomaterials. Equipments. Material. Instrumentation</subject><ispartof>International journal of radiation oncology, biology, physics, 2004-11, Vol.60 (4), p.1120-1126</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-b32cf3b27e8ba643068dff266f01a6ce2caa8b4363563deaf9f9684ca5f8377a3</citedby><cites>FETCH-LOGICAL-c454t-b32cf3b27e8ba643068dff266f01a6ce2caa8b4363563deaf9f9684ca5f8377a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301604009563$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16265201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15519783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Igaki, Hiroshi</creatorcontrib><creatorcontrib>Tokuuye, Koichi</creatorcontrib><creatorcontrib>Okumura, Toshiyuki</creatorcontrib><creatorcontrib>Sugahara, Shinji</creatorcontrib><creatorcontrib>Kagei, Kenji</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><creatorcontrib>Ohara, Kiyoshi</creatorcontrib><creatorcontrib>Hashimoto, Takayuki</creatorcontrib><creatorcontrib>Tsuboi, Koji</creatorcontrib><creatorcontrib>Takano, Shingo</creatorcontrib><creatorcontrib>Matsumura, Akira</creatorcontrib><creatorcontrib>Akine, Yasuyuki</creatorcontrib><title>Clinical results of proton beam therapy for skull base chordoma</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>To evaluate clinical results of proton beam therapy for patients with skull base chordoma.
Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0–95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6–123.4 months).
The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery.
Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chordoma - radiotherapy</subject><subject>Chordoma, Skull base</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Proton beams</subject><subject>Protons - therapeutic use</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Retrospective Studies</subject><subject>Skull Base Neoplasms - radiotherapy</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1r3DAQgGFRGppt2n9Qii7tzc7I-rB9aQlLvyDQSwK9ibE8Itra1layC_n3VdiF3HqayzPD8DL2TkAtQJjrQx0OKQ7HugFQNegajHrBdqJr-0pq_esl24E0UMmCL9nrnA8AIESrXrFLobXo207u2Of9FJbgcOKJ8jatmUfPjymuceED4czXB0p4fOQ-Jp5_b9PEB8zE3UNMY5zxDbvwOGV6e55X7P7rl7v99-r257cf-5vbyimt1mqQjfNyaFrqBjRKgulG7xtjPAg0jhqH2A1KGqmNHAl973vTKYfad7JtUV6xj6e75bc_G-XVziE7miZcKG7ZmhaaVsu-QHWCLsWcE3l7TGHG9GgF2Kdw9mBP4exTOAvalnBl7f35_jbMND4vnUsV8OEMMJdcPuHiQn52pjG6AVHcp5OjUuNvoGSzC7Q4GkMit9oxhv9_8g8M543-</recordid><startdate>20041115</startdate><enddate>20041115</enddate><creator>Igaki, Hiroshi</creator><creator>Tokuuye, Koichi</creator><creator>Okumura, Toshiyuki</creator><creator>Sugahara, Shinji</creator><creator>Kagei, Kenji</creator><creator>Hata, Masaharu</creator><creator>Ohara, Kiyoshi</creator><creator>Hashimoto, Takayuki</creator><creator>Tsuboi, Koji</creator><creator>Takano, Shingo</creator><creator>Matsumura, Akira</creator><creator>Akine, Yasuyuki</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041115</creationdate><title>Clinical results of proton beam therapy for skull base chordoma</title><author>Igaki, Hiroshi ; Tokuuye, Koichi ; Okumura, Toshiyuki ; Sugahara, Shinji ; Kagei, Kenji ; Hata, Masaharu ; Ohara, Kiyoshi ; Hashimoto, Takayuki ; Tsuboi, Koji ; Takano, Shingo ; Matsumura, Akira ; Akine, Yasuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-b32cf3b27e8ba643068dff266f01a6ce2caa8b4363563deaf9f9684ca5f8377a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chordoma - radiotherapy</topic><topic>Chordoma, Skull base</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Proton beams</topic><topic>Protons - therapeutic use</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Retrospective Studies</topic><topic>Skull Base Neoplasms - radiotherapy</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Igaki, Hiroshi</creatorcontrib><creatorcontrib>Tokuuye, Koichi</creatorcontrib><creatorcontrib>Okumura, Toshiyuki</creatorcontrib><creatorcontrib>Sugahara, Shinji</creatorcontrib><creatorcontrib>Kagei, Kenji</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><creatorcontrib>Ohara, Kiyoshi</creatorcontrib><creatorcontrib>Hashimoto, Takayuki</creatorcontrib><creatorcontrib>Tsuboi, Koji</creatorcontrib><creatorcontrib>Takano, Shingo</creatorcontrib><creatorcontrib>Matsumura, Akira</creatorcontrib><creatorcontrib>Akine, Yasuyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Igaki, Hiroshi</au><au>Tokuuye, Koichi</au><au>Okumura, Toshiyuki</au><au>Sugahara, Shinji</au><au>Kagei, Kenji</au><au>Hata, Masaharu</au><au>Ohara, Kiyoshi</au><au>Hashimoto, Takayuki</au><au>Tsuboi, Koji</au><au>Takano, Shingo</au><au>Matsumura, Akira</au><au>Akine, Yasuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical results of proton beam therapy for skull base chordoma</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2004-11-15</date><risdate>2004</risdate><volume>60</volume><issue>4</issue><spage>1120</spage><epage>1126</epage><pages>1120-1126</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>To evaluate clinical results of proton beam therapy for patients with skull base chordoma.
Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0–95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6–123.4 months).
The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery.
Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15519783</pmid><doi>10.1016/j.ijrobp.2004.05.064</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Chordoma - radiotherapy Chordoma, Skull base Female Humans Male Medical sciences Middle Aged Proton beams Protons - therapeutic use Radiotherapy Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Skull Base Neoplasms - radiotherapy Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Clinical results of proton beam therapy for skull base chordoma |
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