Clinical results of proton beam therapy for skull base chordoma

To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2004-11, Vol.60 (4), p.1120-1126
Hauptverfasser: Igaki, Hiroshi, Tokuuye, Koichi, Okumura, Toshiyuki, Sugahara, Shinji, Kagei, Kenji, Hata, Masaharu, Ohara, Kiyoshi, Hashimoto, Takayuki, Tsuboi, Koji, Takano, Shingo, Matsumura, Akira, Akine, Yasuyuki
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Sprache:eng
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Zusammenfassung:To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0–95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6–123.4 months). The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors
ISSN:0360-3016
1879-355X
DOI:10.1016/j.ijrobp.2004.05.064