Estrogen-like compounds for ischemic neuroprotection

We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are pote...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stroke (1970) 2004-11, Vol.35 (11 Suppl 1), p.2648-2651
Hauptverfasser:	Simpkins, James W, Yang, Shao-Hua, Liu, Ran, Perez, Evelyn, Cai, Zu Yun, Covey, Douglas F, Green, Pattie S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Estradiol Congeners - chemistry Estradiol Congeners - pharmacology Estradiol Congeners - therapeutic use Humans Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Rats Receptors, Estrogen Reperfusion Injury - drug therapy Stroke - drug therapy Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.str.0000143734.59507.88