Night/Day Changes in Pineal Expression of >600 Genes: CENTRAL ROLE OF ADRENERGIC/cAMP SIGNALING

The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip® technology to obtain a more complete description of pineal ce...

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Veröffentlicht in:	The Journal of biological chemistry 2009-03, Vol.284 (12), p.7606-7622
Hauptverfasser:	Bailey, Michael J, Coon, Steven L, Carter, David A, Humphries, Ann, Kim, Jong-so, Shi, Qiong, Gaildrat, Pascaline, Morin, Fabrice, Ganguly, Surajit, Hogenesch, John B, Weller, Joan L, Rath, Martin F, Møller, Morten, Baler, Ruben, Sugden, David, Rangel, Zoila G, Munson, Peter J, Klein, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circadian Rhythm - physiology Cyclic AMP - metabolism Gene Expression Profiling - methods Gene Expression Regulation - physiology Norepinephrine - metabolism Oligonucleotide Array Sequence Analysis - methods Organ Specificity Pineal Gland - metabolism Rats Rats, Sprague-Dawley Retina - metabolism
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Zusammenfassung:	The pineal gland plays an essential role in vertebrate chronobiology by converting time into a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the rodent pineal transcriptome using Affymetrix GeneChip® technology to obtain a more complete description of pineal cell biology. The effort revealed that 604 genes (1,268 probe sets) with Entrez Gene identifiers are differentially expressed greater than 2-fold between midnight and mid-day (false discovery rate
ISSN:	0021-9258 1083-351X
DOI:	10.1074/jbc.M808394200