Alternative splicing of interleukin-6 mRNA in mice

Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2004-07, Vol.138 (1), p.73-76
Hauptverfasser:	Yatsenko, O P, Filipenko, M L, Khrapov, E A, Voronina, E N, Sennikov, S V, Kozlov, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Binding Sites Crosses, Genetic Erythrocytes - immunology Exons Female Interleukin-6 - chemistry Interleukin-6 - genetics Mice Mice, Inbred C57BL Mice, Inbred CBA Molecular Sequence Data Placenta - metabolism Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Protein Biosynthesis Protein Isoforms - chemistry Protein Structure, Secondary RNA, Messenger - metabolism Sequence Deletion Sequence Homology, Amino Acid Sheep Spleen - metabolism
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Beschreibung
Zusammenfassung:	Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/BF02694480