Zn(II) complex for selective and rapid scission of protein backbone

Zn(II) complex for selective and rapid scission of protein backbone

A ZnII complex with an aldehyde group hydrolyzed porcine pancreatic elastase under mild conditions, pH 8.0, 50 degrees C, by the Schiff base formation between the ZnII complex and the NH2 group in the protein, suggesting that a ZnII compound can be active toward peptide hydrolysis when it strongly b...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (12), p.1544-1546
Hauptverfasser: Yashiro, Morio, Kawakami, Yukiko, Taya, Jun-ichi, Arai, Suguru, Fujii, Yuki
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Macromolecular Substances - chemistry
Models, Molecular
Molecular Structure
Pancreatic Elastase - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Swine
Zinc - chemistry
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Zusammenfassung:A ZnII complex with an aldehyde group hydrolyzed porcine pancreatic elastase under mild conditions, pH 8.0, 50 degrees C, by the Schiff base formation between the ZnII complex and the NH2 group in the protein, suggesting that a ZnII compound can be active toward peptide hydrolysis when it strongly binds to the substrate.
ISSN:1359-7345
1364-548X
DOI:10.1039/b818022a