Exploiting a Bacterial Drug-Resistance Mechanism: A Light-Activated Construct for the Destruction of MRSA

A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of β-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards β-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mech...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (12), p.2148-2151
Hauptverfasser:	Zheng, Xiang, Sallum, Ulysses W, Verma, Sarika, Athar, Humra, Evans, Conor L, Hasan, Tayyaba
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Lactamases - metabolism beta-Lactamases - radiation effects beta-Lactamases - toxicity drug resistance Kinetics lactams Methicillin-Resistant Staphylococcus aureus - metabolism Methicillin-Resistant Staphylococcus aureus - radiation effects Microbial Sensitivity Tests photochemistry Photochemotherapy photodynamic therapy photosensitizers Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Prodrugs - chemistry Prodrugs - pharmacology Staphylococcus aureus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of β-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards β-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the β-lactam ring) releases the phototoxic component from the prodrug (see picture; Q=quencher).
ISSN:	1433-7851 1521-3773 1521-3773
DOI:	10.1002/anie.200804804