Effects of Losartan and Chlorthalidone on Blood Pressure and Renal Vascular Resistance Index in Non-Diabetic Patients with Essential Hypertension and Normal Renal Function

Effects of Losartan and Chlorthalidone on Blood Pressure and Renal Vascular Resistance Index in Non-Diabetic Patients with Essential Hypertension and Normal Renal Function

Antihypertensive drugs can differ in target organ protection despite similar blood pressure (BP) control. We compared the effects of losartan (L) and chlorthalidone (C) on renal vascular resistance index (RVRI) in 194 grade I to II, non-diabetic hypertensive patients with increased RVRI (>0.68 m/...

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Veröffentlicht in:Journal of cardiovascular pharmacology 2004-11, Vol.44 (5), p.520-524
Hauptverfasser: Caruso, D, D'Avino, M, Acampora, C, Romano, L, Bevilacqua, N, Caruso, G, Esposti, D Degli, Borghi, C
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood Pressure - drug effects
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory - methods
Chlorthalidone - pharmacology
Chlorthalidone - therapeutic use
Cross-Over Studies
Data Interpretation, Statistical
Drug Administration Schedule
Echocardiography, Doppler - methods
Female
Follow-Up Studies
Humans
Hypertension - diagnosis
Hypertension - drug therapy
Kidney Cortex - blood supply
Kidney Cortex - drug effects
Kidney Function Tests - methods
Losartan - pharmacology
Losartan - therapeutic use
Male
Middle Aged
Renal Circulation - drug effects
Renal Circulation - physiology
Single-Blind Method
Time Factors
Treatment Outcome
Vascular Resistance - drug effects
Vascular Resistance - physiology
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Zusammenfassung:Antihypertensive drugs can differ in target organ protection despite similar blood pressure (BP) control. We compared the effects of losartan (L) and chlorthalidone (C) on renal vascular resistance index (RVRI) in 194 grade I to II, non-diabetic hypertensive patients with increased RVRI (>0.68 m/s by echo-Doppler) but normal renal function. Patients were randomly allocated to C 25 mg/d or L 50 mg/d according to a single blind, PROBE study design. After 4 weeks of treatment, 92 patients (48 L/44 C) with BP
ISSN:0160-2446
1533-4023
DOI:10.1097/00005344-200411000-00002