Novel Mannich ketones of oxazolidinones as antibacterial agents

A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compoun...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2004-11, Vol.39 (11), p.989-992
Hauptverfasser:	Srivastava, Brijesh Kumar, Kapadnis, Prashant B., Pandya, Purvi, Lohray, Vidya Bhushan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacillus subtilis - drug effects Biological and medical sciences Enterococcus faecalis - drug effects Eperezolid Gram-positive organism In-vitro MIC Ketones - chemical synthesis Ketones - chemistry Ketones - pharmacology Linezolid Mannich ketones Medical sciences Microbial Sensitivity Tests Oxazolidinone Oxazolidinones - chemical synthesis Oxazolidinones - chemistry Oxazolidinones - pharmacology Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compound 12 showed comparable activity (MIC) to linezolid and superior to eperezolid.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2004.07.007