Preimplantation genetic screening in a case of recurrent trisomy 21 offspring

Objective To describe a unique case of recurrent aneuploidy and the use of preimplantation genetic screening (PGS). Design Case report. Setting Midwest academic medical center. Patient(s) A 36-year-old woman with two trisomy 21 offspring. Intervention(s) Preimplantation genetic screening. Main Outcome Measure(s) Karyotype of embryos, liveborn eukaryotic infant. Result(s) Preimplantation genetic screening was performed on three cryopreserved embryos, followed by a two-embryo transfer yielding a eukaryotic infant. Conclusion(s) Preimplantation genetic screening may prove to be useful as a diagnostic tool to help ensure a euploid pregnancy when termination is not a viable option for a couple.