Posterior fossa neoplasm and PHACES syndrome: a case report

A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck,...

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Veröffentlicht in:Journal of pediatric hematology/oncology 2009-03, Vol.31 (3), p.203-205
Hauptverfasser: Wallen, Katharine E, Hadar, Eldad J, Perry, Victor, Bouldin, Thomas W, Loehr, James, Blatt, Julie
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Sprache:eng
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Zusammenfassung:A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas. Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized. Cerebellar pilocytic astrocytoma may be a rare manifestation of the posterior fossa malformations of PHACES.
ISSN:1077-4114
1536-3678
DOI:10.1097/MPH.0b013e3181983b15