Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients

To determine whether daily dimethylglycine supplementation affects plasma homocysteine concentrations. A randomized, blinded, crossover design was used. Seven pre-dialysis chronic renal failure patients consumed 400 mg of dimethylglycine or placebo daily for 28 days. Fasting blood samples and 12-h urine samples were collected at baseline and at the end of each treatment period for analysis. No significant differences were observed in plasma homocysteine ( P = 0.624), glycine betaine ( P = 0.452) and methionine ( P = 0.457) concentrations between dimethylglycine and placebo treatments. Daily supplementation with dimethylglycine does not affect plasma homocysteine.