Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways

Ovarian cancer is the most lethal type of gynecologic cancer in the Western world. The high case fatality rate is due in part because most ovarian cancer patients present with advanced stage disease which is essentially incurable. In order to obtain a whole genome assessment of aberrant gene express...

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Veröffentlicht in:	Oncogene 2004-10, Vol.23 (49), p.8065-8077
Hauptverfasser:	Donninger, Howard, Bonome, Tomas, Radonovich, Mike, Pise-Masison, Cynthia A, Brady, John, Shih, Joanna H, Barrett, J Carl, Birrer, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis Biological and medical sciences Carcinoma Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Cell Biology Cell differentiation Cell migration Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular signal transduction Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology DNA microarrays Epithelium Female Female genital diseases Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Genome Genomes Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Matrix Metalloproteinases, Membrane-Associated Medical sciences Medicine Medicine & Public Health Metalloendopeptidases - physiology Molecular and cellular biology Neoplasm Staging Oligonucleotide Array Sequence Analysis Oligonucleotides Oncology original-paper Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Polymerase Chain Reaction Signal Transduction Therapeutic targets Tumorigenesis Tumors
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Zusammenfassung:	Ovarian cancer is the most lethal type of gynecologic cancer in the Western world. The high case fatality rate is due in part because most ovarian cancer patients present with advanced stage disease which is essentially incurable. In order to obtain a whole genome assessment of aberrant gene expression in advanced ovarian cancer, we used oligonucleotide microarrays comprising over 40 000 features to profile 37 advanced stage papillary serous primary carcinomas. We identified 1191 genes that were significantly ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/sj.onc.1207959