tRNA Maturation: RNA Polymerization without a Nucleic Acid Template

The CCA-adding enzyme, which builds and repairs the 3′ terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.

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Veröffentlicht in:	Current biology 2004-10, Vol.14 (20), p.R883-R885
1. Verfasser:	Weiner, Alan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaeoglobus fulgidus - genetics Archaeoglobus fulgidus - metabolism Bacteria - genetics Bacteria - metabolism Binding Sites - genetics Models, Genetic RNA Nucleotidyltransferases - chemistry RNA Nucleotidyltransferases - genetics RNA Nucleotidyltransferases - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism
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Beschreibung
Zusammenfassung:	The CCA-adding enzyme, which builds and repairs the 3′ terminal CCA sequence of tRNA, is the only RNA polymerase that can synthesize a defined nucleotide sequence without using a nucleic acid template. New cocrystal structures tell us how this remarkable enzyme works.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2004.09.069