The First Regioselective Palladium-Catalyzed Indolization of 2-Bromo- or 2-Chloroanilines with Internal Alkynes:  A New Approach to 2,3-Disubstituted Indoles

The First Regioselective Palladium-Catalyzed Indolization of 2-Bromo- or 2-Chloroanilines with Internal Alkynes:  A New Approach to 2,3-Disubstituted Indoles

The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.

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Veröffentlicht in:Organic letters 2004-10, Vol.6 (22), p.4129-4132
Hauptverfasser: Shen, Ming, Li, Guisheng, Lu, Bruce Z, Hossain, Azad, Roschangar, Frank, Farina, Vittorio, Senanayake, Chris H
Format: Artikel
Sprache:eng
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Zusammenfassung:The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048114t