Idiopathic Infantile Pyoderma Gangrenosum with Stridor Responsive to Infliximab

: A 4‐month‐old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Com...

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Veröffentlicht in:	Pediatric dermatology 2009-01, Vol.26 (1), p.65-69
Hauptverfasser:	Rajan, Neil, Das, Sharmila, Taylor, Aileen, Abinun, Mario, Spencer, David, Carmichael, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - administration & dosage Antibodies, Monoclonal - administration & dosage Biological and medical sciences Bronchi - pathology Dermatology Female General aspects Humans Infant Infliximab Medical sciences Pyoderma Gangrenosum - complications Pyoderma Gangrenosum - drug therapy Pyoderma Gangrenosum - pathology Respiratory Mucosa - pathology Respiratory Sounds - etiology Skin - pathology Skin involvement in other diseases. Miscellaneous. General aspects Trachea - pathology
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Zusammenfassung:	: A 4‐month‐old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Complete resolution followed treatment with infliximab. We review this rare condition in infants and discuss treatment with infliximab not previously described in this age group.
ISSN:	0736-8046 1525-1470
DOI:	10.1111/j.1525-1470.2008.00825.x