The BOLD response: a new look at an old riddle

Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size...

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Veröffentlicht in:	Neuroreport 2004-09, Vol.15 (13), p.1997-2000
Hauptverfasser:	Marcar, Valentine L, Loenneker, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - blood supply Brain - cytology Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging - methods Models, Neurological Neurons - metabolism Oxygen - blood Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size of the activated neuronal population. These two components are argued to have opposing influences on the BOLD signal. The influence of these two components on the BOLD signal, are summarised in the standard model.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200409150-00001