Regional accumulation of aluminium in the rat brain is affected by dietary vitamin E

The regional accumulation of aluminium in the brain of male albino Wistar rats was investigated following 4 weeks of administration by intraperitoneal injection of aluminium lactate (10 mg aluminium/kg body weight). The consequences of concomitant dietary vitamin E (5, 15, or 20 mg vitamin E/g of fo...

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Veröffentlicht in:	Journal of trace elements in medicine and biology 2004-01, Vol.18 (1), p.53-59
Hauptverfasser:	Abubakar, M.G., Taylor, Andrew, Ferns, Gordon A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminium Aluminum Compounds - administration & dosage Aluminum Compounds - metabolism Animals Antioxidants - administration & dosage Antioxidants - metabolism Biomarkers Body Weight Brain - anatomy & histology Brain - metabolism Catalase - metabolism Dietary Supplements Glutathione - metabolism Lactates - administration & dosage Lactates - metabolism Male Oxidative Stress Random Allocation Rat brain Rats Rats, Wistar Reactive Oxygen Species - metabolism Vitamin E Vitamin E - administration & dosage Vitamin E - metabolism
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Zusammenfassung:	The regional accumulation of aluminium in the brain of male albino Wistar rats was investigated following 4 weeks of administration by intraperitoneal injection of aluminium lactate (10 mg aluminium/kg body weight). The consequences of concomitant dietary vitamin E (5, 15, or 20 mg vitamin E/g of food) were also studied. Rat brains were dissected into functional regions, for the measurement of aluminium and markers of oxidative stress. Plasma aluminium levels were increased in all groups of animals receiving aluminium lactate ( p
ISSN:	0946-672X 1878-3252
DOI:	10.1016/j.jtemb.2004.02.001