Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission
The study was aimed to investigate whether quantities of CD8 + T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8 + T cells. CD8 + T...
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Veröffentlicht in: | Clinical rheumatology 2009-04, Vol.28 (4), p.385-389 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The study was aimed to investigate whether quantities of CD8
+
T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8
+
T cells. CD8
+
T cell subsets were analyzed in 17 JIA patients and 32 age-matched HD by flow cytometry. JIA patients showed lower CD3
+
CD8
+
T cells compared to HD. Total counts of CD8
+
CD28
+
and CD8
+
CD28
+
CD45RA
+
T cells were inversely correlated to chronological age in JIA patients and HD. In JIA patients, percentages of CD8
+
CD28
+
CD45RA
+
T cells and of CD62L-expressing CD8
+
CD28
+
CD45RA
+
T cells showed a negative correlation with age. The trend to lower CD28
+
CD45RA
+
T cell proportions in aged JIA patients in remission may reflect a disturbed T cell homeostasis independently of disease activity and may be due to an intrinsic effect in reconstitution of the peripheral T cells. |
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ISSN: | 0770-3198 1434-9949 |
DOI: | 10.1007/s10067-008-1057-z |