Neurons and glia: team players in axon guidance

In the developing nervous system, growth cones follow specific trajectories to reach their target area and ultimately connect with their correct postsynaptic partners. This review focuses on studies in both Drosophila and vertebrates to highlight that mutual interactions between neurons and glia are essential in forming specific neuronal connections. Glia signal to neurons to direct pathfinding and targeting of axons, as well as to stabilize and refine axonal branches within the target area. Equally, neurons provide crucial information to glia, supporting their migration and correct positioning.