Ninety-Six—Week Efficacy of Combination Therapy with Lamivudine and Tenofovir in Patients Coinfected with HIV-1 and Wild-Type Hepatitis B Virus

We describe 6 patients who were coinfected with human immunodeficiency virus (HIV) type 1 and wild-type hepatitis B virus (HBV), in whom complete and sustained antiviral activity against wild-type HBV strains was attained during 96 weeks of combination therapy with lamivudine and tenofovir. The use...

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Veröffentlicht in:	Clinical infectious diseases 2004-10, Vol.39 (7), p.1062-1064
Hauptverfasser:	Bani-Sadr, F., Palmer, P., Scieux, C., Molina, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adult AIDS Anti-HIV Agents - therapeutic use Antibodies Biological and medical sciences DNA Drug Therapy, Combination Female Hepatitis antigens Hepatitis B Hepatitis B - complications Hepatitis B - drug therapy Hepatitis B virus HIV HIV 1 HIV Infections - complications HIV Infections - drug therapy HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Lamivudine - therapeutic use Male Medical sciences Middle Aged Organophosphonates - therapeutic use RNA Tenofovir Viral diseases Viral diseases of the digestive system Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis
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Zusammenfassung:	We describe 6 patients who were coinfected with human immunodeficiency virus (HIV) type 1 and wild-type hepatitis B virus (HBV), in whom complete and sustained antiviral activity against wild-type HBV strains was attained during 96 weeks of combination therapy with lamivudine and tenofovir. The use of combination therapy with lamivudine and tenofovir for the treatment of HBV infection is very promising in the treatment of HIV/HBV coinfection.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/424012